Core Chemical & Physical Properties
Appearance: White to off-white crystalline solid.
Melting Point: 79–82 °C (literature value).
Boiling Point: 283.5 °C at 760 mmHg; 144–145 °C under 12 Torr.
Density: 1.25±0.1 g/cm³ (predicted).
Solubility: Moderately soluble in organic solvents (DMSO, DMF, ethanol); nearly insoluble in water (1.6 g/L at 25 °C).
Stability: Stable under ambient conditions; store under inert gas (nitrogen/argon) at 2–8 °C to prevent oxidation.
pKa: 2.84±0.20 (predicted), indicating weak acidity.
Industrial Applications
Pharmaceutical Intermediate: A critical precursor for synthesizing anti-inflammatory, antitumor, and antimicrobial drugs. It serves as a key building block for quinazolinone derivatives, which exhibit potent biological activities such as inhibiting tumor cell proliferation and reducing inflammation.
Agrochemicals: Used in developing high-efficiency herbicides, fungicides, and plant growth regulators. Its derivatives act as protoporphyrinogen IX oxidase (PPO) inhibitors, effectively controlling broadleaf weeds while ensuring crop safety.
Fine Chemicals & Materials: Applied in synthesizing functional polymers, dyes, and biochemical reagents. Its dual reactive sites enable efficient substitution and cyclization reactions, supporting the production of high-value-added fine chemicals with low by-product rates.
Research & Development: A standard reference compound in medicinal chemistry and organic synthesis research, widely used in academic institutions and pharmaceutical R&D centers for new drug discovery and mechanism studies.